Why the study?
Does the route of administration determine the myocardial and systemic distribution of basic fibroblast growth factor?
Population
Mongrel dogs
Comparison
125I labeled human recombinant bFGF delivered… vs Comparison among the different delivery routes
Design
Preclinical
Follow-up
15 min or 150 min
Authors
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Supports route optimization research in animal models; leaves open clinical translation and human dosing studies.
Does the route of administration determine the myocardial and systemic distribution of basic fibroblast growth factor?
The route of administration significantly impacts myocardial uptake of bFGF, with intracoronary and pericardial routes being far more effective than intravenous delivery.
Lazarous et al. (1997) studied this question.
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