Effects of the Local Changes in the Mechanical Properties of the Blood Vessel Wall on Pulse Waveforms: A Fluid–Structure Interaction Analysis

Atherosclerosis is a major risk factor for cardiovascular diseases, and its diagnosis is crucial at an early stage.carotid ultrasonography is the current primary diagnostic method for atherosclerosis.However, carotid ultrasonography has problems in the early detection and evaluation of the mechanical properties of the arterial wall.To address these issues, waveform analysis focusing on pulse wave propagation has garnered attention.Despite its potential, few studies have performed pulse wave separation in an environment where pulse waves interfere with each other, as in vivo, and evaluated the reflected waveforms using three-dimensional fluid-structure interaction (FSI) analysis.In this study, pulse wave propagation was reproduced to investigate the relationship between local changes in the mechanical properties of the arterial wall and the reflected waveforms.Using a threedimensional cylindrical model, coupled FSI analysis was performed with commercial codes by Altair.The results showed that an increase in Young's modulus amplified the reflected wave amplitudes and elongated the wavelengths.The results also showed trends similar to the theoretical reflection coefficients, particularly for larger changes in Young's modulus, which closely aligned with the theoretical values.These findings indicate that evaluating reflected waves can lead to estimating the local mechanical properties of the arterial walls.