November 1, 1995Circulation Research
Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K+Channel?
Population
Human right atrial trabeculae
Comparison
Ischemic preconditioning, cromakalim, or… vs Nonpreconditioned controls
Design
Preclinical
Follow-up
120 minutes of reperfusion
Authors
Discussion
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Member takes
Implication
Highlights PKC-KATP pathway in preconditioning; leaves open clinical translation from this animal model.
Structured PICO
P
Population
Human right atrial trabeculae
I
Intervention
Ischemic preconditioning (3 minutes of simulated ischemia and 7 minutes of reperfusion), cromakalim (K ATP channel opener), or 1,2-dioctanoyl-sn-glycerol (PKC activator)
C
Comparator
Nonpreconditioned controls
O
Outcome
Recovery of contractile function after simulated ischemia (percentage recovery of baseline function)surrogate
Ischemic preconditioning in human myocardium appears to act via protein kinase C activation and relies on the ATP-dependent K+ channel as the end effector.
Cite This Study
Speechly-Dick et al. (1995) studied this question.