Prohibitin-2 Binding Modulates Insulin-like Growth Factor-binding Protein-6 (IGFBP-6)-induced Rhabdomyosarcoma Cell Migration

View Full Paper

Ask AI

Bookmark

Population

Rhabdomyosarcoma (RMS) cells

Design

Preclinical

Authors

Discussion

May support PHB2 as a target in rhabdomyosarcoma; leaves open translation from animal data.

Population

Rhabdomyosarcoma (RMS) cells

Intervention

IGFBP-6 exposure and PHB2 knockdown

Outcome

RMS cell migration and molecular interactions between IGFBP-6 and PHB2surrogate

Prohibitin-2 is required for IGFBP-6-induced rhabdomyosarcoma cell migration, suggesting it may be a novel target to inhibit cancer cell migration.

Fu et al. (2013) studied this question.

View Full Paper

Ask AI

Bookmark