What question did this study set out to answer?

To evaluate the preoperative diagnostic performance of systemic inflammatory markers, specifically neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), in newly diagnosed colorectal cancer patients.

January 17, 2019Disease MarkersOpen Access

Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer

View Full Paper

Ask AI

Bookmark

Authors

MLMilica Stojković LaloševićUniversity of Belgrade AMAleksandra Pavlović MarkovićUniversity of Kragujevac SSSanja StankovićPreventive Cardiology

Discussion

Member takes

Implication

Case-control study demonstrates high diagnostic efficacy of combined inflammatory blood markers in colorectal cancer, suggesting their clinical utility for early tumor detection.

Key Points

To evaluate the preoperative diagnostic performance of systemic inflammatory markers, specifically neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), in newly diagnosed colorectal cancer patients.
Conducted a case-control study assessing complete blood counts with automated differential counts in 300 colorectal cancer patients and 300 healthy volunteers.
Calculated NLR and PLR from absolute blood cell counts and evaluated individual and combined diagnostic accuracy using receiver operating characteristic (ROC) curves.
Individual markers showed significant diagnostic accuracy, with NLR achieving an AUC of 0.790 (95% CI 0.736–0.884; cut-off 2.15, sensitivity 74.1%, specificity 73%) and PLR achieving an AUC of 0.846 (95% CI 0.801–0.891; cut-off 123, sensitivity 73.5%, specificity 80%).
Combining NLR, PLR, and MPV demonstrated superior diagnostic efficacy compared to any single marker (AUC 0.904, 95% CI 0.812–0.989, sensitivity 96%, specificity 70%).

Cite This Study

Lalošević et al. (2019) studied this question.

synapsesocial.com/papers/6a81679a077e7aa907c439be https://doi.org/10.1155/2019/6036979

View Full Paper

Ask AI

Bookmark

Implication

Case-control study demonstrates high diagnostic efficacy of combined inflammatory blood markers in colorectal cancer, suggesting their clinical utility for early tumor detection.

Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider