Why the study?
Does ablation of the subfornical organ reduce water intake elicited by systemically administered angiotensin-II in a preclinical model?
Does ablation of the subfornical organ reduce water intake elicited by systemically administered angiotensin-II in a preclinical model?
The subfornical organ acts as a receptor site for angiotensin-II mediating water intake, though other receptor sites likely exist.
Subfornical organ lesions attenuate but do not abolish angiotensin-II thirst in rodents; leaves open redundant central sites for further mapping.
The effect of electrolytic lesions of the subfornical organ on water intake induced by the continuous infusion of angiotensin-II through a chronic jugular cannula was studied. Lesions of the subfornical organ significantly reduced but did not abolish the elicited drinking. These results support the hypothesis that the subfornical organ is a receptor site for angiotensin-II but also suggest that this may not be the only site of receptors.
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Abdelaal et al. (1974) studied this question.
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