Key result
Subfornical organ ablation cuts angiotensin-induced drinking by ~96% in dogs without altering response to hypertonic saline.
Why the study?
The role of the subfornical organ in drinking responses to cellular dehydration and angiotensin in the dog was unclear.
Answers are grounded in this paper and cite their sources.
SFO ablation abolishes angiotensin- but not hypertonic saline-induced drinking in dogs; leaves open its necessity in human fluid homeostasis.
The role of the subfornical organ (SFO) in drinking caused by cellular dehydration and angiotensin was examined in the dog. Drinking responses to intravenous administration of angiotensin and to hypertonic NaCl were compared before and after electrolytic ablation of the SFO. After destruction of the SFO, drinking in response to angiotensin was 0.5 +/- 0.3 ml/kg compared to 11.9 +/- 3.7 ml/kg prior to lesioning. Drinking in response to hypertonic NaCl was not affected by lesioning the SFO (12.6 +/- 6.6 ml/kg before vs. 13.4 +/- 5.4 ml/kg after the lesion). Lesions superior or lateral to the SFO did not affect drinking in response to either angiotensin or hypertonic NaCl. These data show that the SFO is essential for drinking in response to blood-borne angiotensin but not to the stimulus of cellular dehydration in the dog.
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Thrasher et al. (2008) studied Angiotensin-induced drinking. Electrolytic ablation of the subfornical organ (SFO) vs. Prior to lesioning (baseline) was evaluated on Drinking in response to angiotensin. Electrolytic ablation of the subfornical organ in dogs reduced drinking in response to angiotensin from 11.9 ml/kg to 0.5 ml/kg, but did not affect drinking in response to hypertonic NaCl.
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