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September 10, 2013CirculationOpen Access

Sevoflurane Preconditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Caveolin-3–Dependent Cyclooxygenase-2 Inhibition

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Why the study?

Does sevoflurane preconditioning reduce myocardial ischemia/reperfusion injury in mouse models?

Population

Wild-type mice, cardiac-specific AMPKα2 dominant-negative overexpressing mice, and Cav-3 knockout mice…

Comparison

Sevoflurane preconditioning consisting of 3… vs No preconditioning (implied)

Design

Preclinical

Authors

JZJianli ZhaoXinHua HospitalFWFeng WangTongji HospitalYZYanqing ZhangGeorgia State University

Discussion

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Implication

No immediate clinical implications for anesthetic preconditioning; leaves open whether caveolin-3 dependence extends to human ischemia/reperfusion injury.

Structured PICO

Does sevoflurane preconditioning reduce myocardial ischemia/reperfusion injury in mouse models?

P
Population
Wild-type mice, cardiac-specific AMPKα2 dominant-negative overexpressing mice, and Cav-3 knockout mice subjected to myocardial ischemia/reperfusion (MI/R) injury
I
Intervention
Sevoflurane preconditioning (SF-PreCon) consisting of 3 cycles of 15-minute exposure to 2% sevoflurane before 30 minutes of myocardial ischemia
C
Comparator
No preconditioning (implied)
O
Outcome
Myocardial ischemia/reperfusion injury measured by caspase-3 activity, infarct size, and left ventricular end-diastolic pressuresurrogate

Sevoflurane preconditioning protects against myocardial ischemia/reperfusion injury via a caveolin-3-dependent cyclooxygenase-2 inhibition mechanism, independent of AMPK.

Cite This Study

Zhao et al. (2013) studied this question.

synapsesocial.com/papers/6a8169e1ada1eccddc33be0ehttps://doi.org/10.1161/circulationaha.112.000045
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reactive Oxygen Species–Induced Stimulation of 5′AMP-Activated Protein Kinase Mediates Sevoflurane-Induced Cardioprotection2009 · 92 citations
  2. 2Differences in Production of Reactive Oxygen Species and Mitochondrial Uncoupling as Events in the Preconditioning Signaling Cascade Between Desflurane and Sevoflurane2009 · 70 citations
  3. 3Role of Caveolin-3 and Glucose Transporter-4 in Isoflurane-induced Delayed Cardiac Protection2010 · 59 citations
  4. 4Effects of Nitrous Oxide on the Rat Heart In Vivo2005 · 36 citations
  5. 5Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation2010 · 314 citations