Why the study?
Does an angiotensin converting-enzyme inhibitor alter blood pressure, renin activity, and aldosterone secretion in normal human subjects during postural changes and varying sodium states?
Population
8 normal human subjects
Comparison
Angiotensin converting-enzyme inhibitor… vs Before administration of CEI
Design
Other
Authors
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CEI may impair postural BP control in sodium depletion; leaves open angiotensin II primacy for aldosterone secretion pending larger trials.
Does an angiotensin converting-enzyme inhibitor alter blood pressure, renin activity, and aldosterone secretion in normal human subjects during postural changes and varying sodium states?
Angiotensin II is essential for blood pressure control in sodium-depleted individuals and serves as the primary stimulus for aldosterone secretion in response to sodium depletion and posture.
Haber et al. (1974) studied this question.
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