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April 1, 2020Pharmacology Research & PerspectivesOpen Access

β2‐adrenergic stimulation induces interleukin‐6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts

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Why the study?

The mechanism underlying pro-inflammatory cytokine expression in cardiac fibroblasts in response to beta-adrenergic stimulation remains to be fully elucidated.

Population

Cardiac fibroblasts isolated from adult wild-type or Arid5a knockout mice

Comparison

Beta-adrenergic stimulation vs unstimulated controls or Arid5a knockout

Design

Preclinical in vitro laboratory study

Authors

STShota TanakaAIAtsuki ImaedaKMKotaro Matsumoto

Discussion

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Member takes

Overview

Should not alter clinical management of cardiac inflammation; leaves open Arid5a as a β2AR-IL-6 mediator in fibroblasts.

Structured PICO

P
Population
Cardiac fibroblasts (CFs) isolated from adult wild-type or AT-rich interactive domain-containing protein 5A (Arid5a) knockout mice
I
Intervention
β-adrenergic stimulation (specifically β2-adrenergic stimulation)
C
Comparator
Unstimulated CFs or Arid5a knockout CFs
O
Outcome
Expression of IL-6 mRNA and protein, and Arid5a expressionsurrogate

β2-adrenergic stimulation upregulates IL-6 expression by inducing Arid5a through the cAMP/PKA/CREB pathway in adult cardiac fibroblasts, highlighting the β2AR/Arid5a/IL-6 axis as a potential target against cardiac inflammation.

Cite This Study

Tanaka et al. (2020) studied this question.

synapsesocial.com/papers/6a816cceada1eccddc33bf18https://doi.org/10.1002/prp2.590
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes2000 · 231 citations
  2. 2Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo2013 · 238 citations
  3. 3Adiponectin induces interleukin‐6 production and activates STAT3 in adult mouse cardiac fibroblasts2008 · 37 citations
  4. 4Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction2016 · 246 citations
  5. 5Cardiac Fibroblast Glycogen Synthase Kinase-3β Regulates Ventricular Remodeling and Dysfunction in Ischemic Heart2014 · 172 citations