Why the study?
Does increasing digoxin dosage reduce ventricular rate at rest and exercise in patients with atrial fibrillation?
Population
14 patients with atrial fibrillation
Comparison
Digoxin in increasing doses from 0.125 mg/day up… vs Different doses of digoxin
Design
Cohort
Follow-up
14-day periods per dose
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High interindividual variability in digoxin response precludes precise rate-based adequacy assessment in AF; leaves open need for alternative monitoring.
Does increasing digoxin dosage reduce ventricular rate at rest and exercise in patients with atrial fibrillation?
Due to significant individual variability, ventricular rate at rest or exercise cannot precisely determine the adequacy of digoxin treatment in patients with atrial fibrillation.
A 1971 study studied this question.
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