Population
Nephrectomized rats, intact rats, and sham-operated rats
Comparison
Isoprenaline preceded by I.V. pig renin vs Isoprenaline alone, or intact/sham-operated rats…
Design
Preclinical
Authors
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No immediate clinical implications in humans; leaves open renin-isoprenaline interactions in experimental thirst models.
Circulating renin plays a permissive role in isoprenaline-induced drinking, suggesting an interaction between angiotensin and isoprenaline at intracranial receptors.
Atkinson et al. (1979) studied this question.
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