Why the study?
Hydroxyethyl starch solutions have been extensively used for intraoperative hypovolemia, but changes in postoperative renal function and coagulation profile required evaluation in patients undergoing orthopedic hip surgery under spinal anesthesia.
Does coloading with 6% HES 130/0.4 compared to Ringer's Lactate affect post-operative renal function and coagulation profile in elderly patients undergoing orthopedic hip surgery under spinal anesthesia?
Population
Seventy patients aged 50 to 80 years undergoing orthopedic hip surgery under spinal anesthesia
Comparison
Coloading with 6% HES 130/0.4 vs Group RL (7.5 mlkg-1)
Design
Prospective study
Follow-up
3rd day of surgery
Authors
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Should not yet change fluid choice in elderly hip surgery; leaves open need for RCTs to confirm HES safety.
Does coloading with 6% HES 130/0.4 compared to Ringer's Lactate affect post-operative renal function and coagulation profile in elderly patients undergoing orthopedic hip surgery under spinal anesthesia?
Tetrastarch (6% HES 130/0.4) can be safely used for intraoperative hypovolemia in elderly patients with normal baseline renal and coagulation profiles undergoing orthopedic hip surgery.
Kamal et al. (2021) studied this question.
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