Why the study?
Does isovolemic replacement of 1-L blood loss with 6% HES compared to 5% human albumin affect blood coagulation in patients undergoing neurosurgery or lower abdominal surgery?
Population
40 patients (20 scheduled for brain tumor surgery and 20 undergoing transabdominal hysterectomy)
Comparison
Isovolemic replacement of 1-L blood loss with 6%… vs Isovolemic replacement of 1-L blood loss with 5%…
Design
Cohort
Follow-up
48 hours postoperatively
Authors
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Supports hemostatic safety of both colloids in these surgeries; hypothesis-generating and requires prospective validation before practice change.
Does isovolemic replacement of 1-L blood loss with 6% HES compared to 5% human albumin affect blood coagulation in patients undergoing neurosurgery or lower abdominal surgery?
Isovolemic replacement of 1-L blood loss with 6% HES or 5% human albumin does not interfere with normal hemostasis during and after neurosurgery or lower abdominal surgery.
Claes et al. (1992) studied this question.
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