March 1, 2012Obstetrical & Gynecological Survey
Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Why the study?
Does becoming nonobese in adulthood after being overweight or obese in childhood reduce the risk of cardiovascular disease risk factors in adulthood?
Population
6328 subjects tracked from childhood into adulthood, pooled from 4 prospective cohort studies.
Comparison
Overweight or obese in childhood who became… vs Individuals with normal BMI in childhood who…
Design
Cohort
Follow-up
23 years
Authors
Discussion
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Member takes
Implication
Supports reversing childhood obesity to normalize adult CV risks; hypothesis-generating, requires prospective trials before practice change.
Structured PICO
Does becoming nonobese in adulthood after being overweight or obese in childhood reduce the risk of cardiovascular disease risk factors in adulthood?
P
Population
6328 subjects tracked from childhood into adulthood, pooled from 4 prospective cohort studies.
I
Intervention
Overweight or obese in childhood who became nonobese as adults (group II), obese in both childhood and adulthood (group III), or normal in childhood and obese as adults (group IV)
C
Comparator
Individuals with normal BMI in childhood who were nonobese as adults (group I)
O
Outcome
Cardiovascular risk factors including type 2 diabetes, hypertension, elevated low-density lipoprotein cholesterol, reduced high-density lipoprotein cholesterol, elevated triglycerides, and carotid artery atherosclerosis (increased intima-media thickness)surrogate
Reversing childhood obesity by adulthood normalizes cardiovascular risk to levels seen in individuals who were never obese, highlighting the importance of weight management interventions.
Cite This Study
Juonala et al. (2012) studied this question.