Strong Association of a Renin Intronic Dimorphism with Essential Hypertension
Why the study?
Is the REN 10631A>G dimorphism associated with essential hypertension in the Emirati population?
Population
689 unrelated Gulf Arabs from the United Arab Emirates
Comparison
REN 10631A>G dimorphism (A allele / AA genotype) vs G allele / GG genotype
Design
Case-control
Authors
Discussion
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Member takes
Implication
GG genotype associated with higher hypertension odds in Emiratis; leaves open replication, causality, and clinical utility.
Structured PICO
Is the REN 10631A>G dimorphism associated with essential hypertension in the Emirati population?
P
Population
689 unrelated Gulf Arabs from the United Arab Emirates (326 first-time clinically diagnosed hypertensives and 363 age- and gender-matched normotensive subjects)
I
Intervention
REN 10631A>G dimorphism (A allele / AA genotype)
C
Comparator
G allele / GG genotype
O
Outcome
Clinical diagnosis of essential hypertension (EHT)
The REN 10631A allele is significantly associated with an increased risk of essential hypertension in the Emirati population, suggesting a recessive genetic effect.
Cite This Study
Ahmad et al. (2005) studied this question.