Key result
REN gene Mbo I polymorphism was not associated with essential hypertension overall, but female A allele carriers showed a trend toward higher risk (OR 1.87; 95% CI 0.98-3.56; p=0.057).
Why the study?
Is the REN gene Mbo I polymorphism associated with essential hypertension in a South Indian population?
Case-Control (n=479)
Is the REN gene Mbo I polymorphism associated with essential hypertension in a South Indian population?
Answers are grounded in this paper and cite their sources.
The REN gene Mbo I polymorphism is not significantly associated with essential hypertension in the overall South Indian population, though there may be a sex-specific trend in females.
BACKGROUND: Renin is a rate-limiting enzyme of the renin-angiotensin-aldosterone system (RAAS) that plays a crucial role in the regulation of blood pressure. The renin gene has been suggested as a marker for genetic predisposition to essential hypertension (EHT) in humans. The purpose of the study is to explore the association of a genetic marker of renin gene Mbo I polymorphism with EHT in the South Indian population. METHODS: A total of 279 hypertensive and 200 normotensive subjects were genotyped for REN Mbo I polymorphism (RFLP) using the PCR-restriction fragment length polymorphism method. RESULTS: There were no significant differences in the distribution of genotypes and alleles for REN gene Mbo I polymorphism between hypertensive cases and controls (p>0.05). The genotypic and allele frequencies were in Hardy-Weinberg equilibrium both in cases and controls. Females with Mbo I AA+GA genotypes had 1.87-fold higher risk to develop hypertension as compared with those with GG genotype (odds ratio 1.87; 95% confidence interval = 0.98-3.56, p = 0.057). CONCLUSIONS: Our results indicate that renin gene Mbo I site polymorphism is not associated with blood pressure levels and risk of hypertension. However, the present study demonstrates risk for females who are carriers of REN Mbo I A allele for developing essential hypertension.
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Vamsi et al. (2012) conducted a case-control in essential hypertension (n=479). REN gene Mbo I polymorphism vs. Normotensive controls / GG genotype was evaluated on essential hypertension (OR 1.87, 95% CI 0.98-3.56, p=0.057). REN gene Mbo I polymorphism was not associated with essential hypertension overall, but female A allele carriers showed a trend toward higher risk (OR 1.87; 95% CI 0.98-3.56; p=0.057).
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