March 1, 1990Circulation
Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis.
Why the study?
Does captopril reduce heart weight and myocardial necrosis in mice with acute coxsackievirus B3 myocarditis?
Population
90 mice infected with coxsackievirus B3 (n=30 in early treatment protocol, n=60 in late treatment protocol)
Comparison
Captopril administered either early or late vs Saline
Design
Preclinical
Follow-up
Up to 30 days
Authors
Discussion
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Member takes
Implication
Preclinical support for early ACE inhibition in murine viral myocarditis; hypothesis-generating and should not change practice.
Structured PICO
Does captopril reduce heart weight and myocardial necrosis in mice with acute coxsackievirus B3 myocarditis?
P
Population
90 mice infected with coxsackievirus B3 (n=30 in early treatment protocol, n=60 in late treatment protocol)
I
Intervention
Captopril administered either early (day 1 through day 6 of infection) or late (day 10 through day 30 of infection)
C
Comparator
Saline
O
Outcome
Heart weight and degree of inflammation, necrosis, and dystrophic calcification (assessed with a semiquantitative histological score and planimetry)surrogate
Captopril reduces heart weight and myocardial necrosis when administered early, and reduces heart weight when administered late in a murine model of viral myocarditis.
Cite This Study
Rezkalla et al. (1990) studied this question.