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November 1, 2008Medicine

Acute Viral Infections in Patients With Systemic Lupus Erythematosus

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Population

88 patients with systemic lupus erythematosus and acute viral infections.

Design

Case_series

Authors

MRManuel Ramos‐CasalsRoche (Switzerland)MCMaría José CuadradoKing's College Hospital NHS Foundation TrustPAPaula AlbaUniversidad Nacional de Córdoba

Discussion

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Implication

Potential mortality predictors in SLE viral infections warrant vigilance; hypothesis-generating and requires validation before guiding care.

Structured PICO

P
Population
88 patients with systemic lupus erythematosus (SLE) and acute viral infections (23 from 3 large teaching hospitals, 65 from literature review).
O
Outcome
Etiology, clinical features, and outcomes (including mortality) of acute viral infections

Acute viral infections in SLE patients, particularly parvovirus B19 and CMV, can mimic lupus flares or present as severe organ-specific or disseminated infections, with mortality associated with renal failure, antiphospholipid syndrome, and cyclophosphamide use.

Cite This Study

Ramos‐Casals et al. (2008) studied this question.

synapsesocial.com/papers/6a81793fd7cc36764366378ehttps://doi.org/10.1097/md.0b013e31818ec711
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An autopsied case of chronic active Epstein-Barr virus infection complicated in systemic lupus erythematosus and antiphospholipid antibody syndrome.2002 · 14 citations
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  3. 3Cross-reaction between antibodies to the major epitope of Ro60 kD autoantigen and a homologous peptide of Coxsackie virus 2B protein2005 · 74 citations
  4. 4Cavitary lung masses in SLE patients: an unusual manifestation of CMV infection2004 · 27 citations