What question did this study set out to answer?

To highlight diagnostic challenges and the risk of misdiagnosis when relying solely on initial muscle biopsy histology in sporadic inclusion body myositis.

August 16, 2026Folia MedicaOpen Access

Sporadic inclusion body myositis: overreliance on histology may lead to misdiagnosis

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Authors

BSBehidzhe Sadarzanska-Terzieva PTPlamen Tzvetanov RRRossen Rousseff

Discussion

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Overview

Case report reveals misdiagnosis of sporadic inclusion body myositis as polymyositis due to initial biopsy limitations, highlighting the necessity of clinical and electrophysiological correlation.

Key Points

To highlight diagnostic challenges and the risk of misdiagnosis when relying solely on initial muscle biopsy histology in sporadic inclusion body myositis.
Assessed clinical progression, electrophysiological features, and serial muscle biopsies in a 57-year-old male presenting with asymmetric finger flexor and quadriceps weakness (N=1).
Monitored clinical response and treatment-related toxicities following initial immunosuppressive therapy.
Initial biopsy revealed endomysial inflammation without rimmed vacuoles, prompting an incorrect diagnosis of polymyositis and harmful, ineffective immunosuppressive treatment.
A repeat biopsy demonstrated characteristic rimmed vacuoles, confirming sporadic inclusion body myositis consistent with the initial clinical pattern of deep finger flexor weakness.

Cite This Study

Sadarzanska-Terzieva et al. (2026) studied this question.

synapsesocial.com/papers/6a81794cf2fb91fc834ac76e https://doi.org/10.3897/folmed.68.e155323

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August 16, 2026Folia MedicaOpen Access

Sporadic inclusion body myositis: overreliance on histology may lead to misdiagnosis

View Full Paper

Ask AI

Bookmark

Authors

BSBehidzhe Sadarzanska-Terzieva PTPlamen Tzvetanov RRRossen Rousseff

Discussion

Member takes

Overview

Case report reveals misdiagnosis of sporadic inclusion body myositis as polymyositis due to initial biopsy limitations, highlighting the necessity of clinical and electrophysiological correlation.

Key Points

To highlight diagnostic challenges and the risk of misdiagnosis when relying solely on initial muscle biopsy histology in sporadic inclusion body myositis.
Assessed clinical progression, electrophysiological features, and serial muscle biopsies in a 57-year-old male presenting with asymmetric finger flexor and quadriceps weakness (N=1).
Monitored clinical response and treatment-related toxicities following initial immunosuppressive therapy.
Initial biopsy revealed endomysial inflammation without rimmed vacuoles, prompting an incorrect diagnosis of polymyositis and harmful, ineffective immunosuppressive treatment.
A repeat biopsy demonstrated characteristic rimmed vacuoles, confirming sporadic inclusion body myositis consistent with the initial clinical pattern of deep finger flexor weakness.

Cite This Study

Sadarzanska-Terzieva et al. (2026) studied this question.

synapsesocial.com/papers/6a81794cf2fb91fc834ac76e https://doi.org/10.3897/folmed.68.e155323

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