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August 16, 2026Indian Journal of Physiology and PharmacologyOpen Access

Pharmacological investigation of Hamelia patens leaves for central nervous system activity in rats

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Authors

SAShreyash Vasudev AzgaonkarLMLiesl Maria Fernandes e MendonçaAKAnanya Rupesh Katkar

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Overview

Preclinical study demonstrates anxiolytic and antioxidant properties of Hamelia patens leaf extracts in rats, suggesting potential therapeutic value for central nervous system disorders.

Key Points

  • To evaluate the in vitro antioxidant capacity, in vivo anxiolytic effects, and in silico GABAA-BZD receptor binding of Hamelia patens leaf extracts in Wistar albino rats.
  • Extracted H. patens leaves with ethanol (EEHP) and fractionated with acetone (AEHP) to assess qualitative phytochemicals and in vitro free radical scavenging (DPPH and nitric oxide).
  • Administered EEHP and AEHP orally at 100 mg/kg and 200 mg/kg daily for 7 days to Wistar albino rats, evaluating behavioral anxiety using the Elevated Plus Maze, Light and Dark Model, Mirror Chamber Apparatus, and locomotor activity compared to diazepam.
  • Performed in silico molecular docking of identified phytoconstituents against the GABAA-BZD receptor.
  • Both EEHP and AEHP exhibited concentration-dependent DPPH and nitric oxide radical scavenging activity and contained bioactive flavonoids, alkaloids, tannins, and triterpenoids.
  • Treatment with both extracts significantly increased open arm entries and time in the Elevated Plus Maze, light compartment parameters, mirror chamber exploration, and resting time relative to controls.
  • In silico docking analysis demonstrated high binding affinity between H. patens phytoconstituents and the GABAA-BZD receptor.

Cite This Study

Azgaonkar et al. (2026) studied this question.

synapsesocial.com/papers/6a817a11f2fb91fc834ada66https://doi.org/10.25259/ijpp_86_2026
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