Why the study?
Does rechallenge with a different potent neuroleptic cause recurrence of Neuroleptic Malignant Syndrome in a patient recovering from an episode?
Does rechallenge with a different potent neuroleptic cause recurrence of Neuroleptic Malignant Syndrome in a patient recovering from an episode?
Rechallenge with a different potent neuroleptic may be safe and effective in treating psychosis after an episode of Neuroleptic Malignant Syndrome.
Answers are grounded in this paper and cite their sources.
Rechallenge with alternative neuroleptic may succeed post-NMS; leaves open broader safety and requires prospective confirmation.
The authors report a case of unequivocal Neuroleptic Malignant Syndrome, in which the patient was successfully rechallenged with a different potent neuroleptic in substantial dosage during the recovery phase. The Neuroleptic Malignant Syndrome did not recur and the patient's psychosis cleared. Reference is made to the relevant world literature.
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Padgett et al. (1989) studied this question.
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