Population
F2 male rats from genetic crosses involving spontaneously hypertensive rats and Wistar-Kyoto rats
Comparison
Inheritance of SHRSP Y chromosome and dietary… vs Reciprocal crosses (WKY Y chromosome)
Design
Preclinical
Authors
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Y chromosome-epistatic effects on salt-sensitive BP in male rats remain hypothesis-generating; no clinical implications yet.
The Y chromosome influences blood pressure in hypertensive rat models through complex epistatic interactions with autosomal loci and ecogenetic interactions with dietary salt.
Kreutz et al. (1996) studied this question.
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