Population
Spontaneously hypertensive rats (SHR) model
Design
Review
Authors
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No immediate clinical implications in humans; leaves open mechanistic studies of Y-linked hypertension.
The Y chromosome in spontaneously hypertensive rats contains a locus, potentially Sry, that significantly increases blood pressure through mechanisms involving testosterone, the sympathetic nervous system, and salt sensitivity.
Ely et al. (2000) studied this question.
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