Key result
SHR Y chromosome accelerates peak testosterone by ~4 weeks and increases blood pressure versus WKY controls.
Why the study?
The relationship between testosterone and blood pressure during the rapid development phase of blood pressure rise in different rat strains was unclear.
Population
Four strains of rats: WKY, SHR, SHR/y, and SHR/a
Comparison
SHR Y chromosome presence vs WKY Y chromosome presence
Design
Preclinical experimental study
Follow-up
From 5 to 23 weeks of age
Authors
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Testosterone may promote BP rise in these rat strains; leaves open whether Y-chromosome or androgen effects apply to human hypertension.
The SHR Y chromosome accelerates the early rise in testosterone and the onset of puberty, which may trigger molecular and neuroendocrine events leading to hypertension.
Ely et al. (1994) studied Hypertension. SHR Y chromosome vs. WKY rat Y chromosome was evaluated on Serum testosterone and blood pressure. The SHR Y chromosome accelerated peak testosterone by approximately 4 weeks and increased blood pressure compared with the WKY rat Y chromosome.
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