What question did this study set out to answer?

To assess the independent effects of vagal nerve stimulation and acetylcholine administration on myocardial contractility, oxygen consumption, and coronary flow when heart rate is kept constant.

September 1, 1957Circulation ResearchOpen Access

Effects of Vagus Stimulation and of Acetylcholine on Myocardial Contractility, O 2 Consumption and Coronary Flow in Dogs

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Authors

GSGÜNTHER L. SCHREINERChildren's Medical Center EBErik BerglundKarolinska Institutet HBHans G. BorstHarvard University

Discussion

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Implication

May caution against equating acetylcholine effects with vagal stimulation in paced hearts; leaves open distinct neural pathways in cardiac control.

Key Points

To assess the independent effects of vagal nerve stimulation and acetylcholine administration on myocardial contractility, oxygen consumption, and coronary flow when heart rate is kept constant.
Maintained a constant heart rate in dogs using an electric pacemaker during experimental protocols.
Delivered vagus nerve stimulation and infused acetylcholine while monitoring ventricular function curves, myocardial oxygen consumption, and coronary blood flow.
Vagus nerve stimulation caused no changes in ventricular function curves, myocardial oxygen consumption, or coronary blood flow during fixed-rate cardiac pacing.
Acetylcholine infusion under constant heart rate produced a decrease in myocardial contractility alongside coronary and peripheral vasodilation.

Cite This Study

SCHREINER et al. (1957) studied this question.

synapsesocial.com/papers/6a81905cb35cb7638cee1cc9 https://doi.org/10.1161/01.res.5.5.562

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Implication

May caution against equating acetylcholine effects with vagal stimulation in paced hearts; leaves open distinct neural pathways in cardiac control.

Effects of Vagus Stimulation and of Acetylcholine on Myocardial Contractility, O 2 Consumption and Coronary Flow in Dogs

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Vagus Stimulation and of Acetylcholine on Myocardial Contractility, O 2 Consumption and Coronary Flow in Dogs

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider