Key result
Elevated admission serum amyloid A levels independently predicted poor functional outcome at 3 months after aneurysmal subarachnoid hemorrhage (OR 1.129).
Why the study?
Inflammation plays a vital role in aneurysmal subarachnoid hemorrhage, but the relationship between serum amyloid A concentrations and prognosis in aSAH needed to be elucidated.
Does elevated serum amyloid A predict poor functional outcome in patients with aneurysmal subarachnoid hemorrhage?
Population
456 patients with aSAH and age- and sex-matched healthy controls
Comparison
Poor vs good outcome groups and healthy controls
Design
Prospective cohort study
Follow-up
3 months
Authors
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May aid prognostication after aneurysmal subarachnoid hemorrhage; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=456)
No
Does elevated serum amyloid A predict poor functional outcome in patients with aneurysmal subarachnoid hemorrhage?
Odds Ratio: 1.129 (95% CI 1.081–1.177)
p-value: p=<0.001
Elevated admission serum amyloid A levels independently predict poor 3-month functional outcomes in patients with aneurysmal subarachnoid hemorrhage, demonstrating better discriminatory ability than CRP or IL-6.
Sun et al. (2023) conducted a cohort in Aneurysmal subarachnoid hemorrhage (n=456). Elevated serum amyloid A (SAA) vs. Lower serum amyloid A (SAA) was evaluated on Poor functional outcome (Glasgow Outcome Scale score 1-3) at 3 months (OR 1.129, 95% CI 1.081-1.177, p=<0.001). Elevated admission serum amyloid A levels independently predicted poor functional outcome at 3 months after aneurysmal subarachnoid hemorrhage (OR 1.129).
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