Key result
Elevated serum soluble ICAM-1 levels over the first 2 weeks post-SAH were significantly associated with poor functional outcome (P<0.01).
Why the study?
Are elevated serum soluble ICAM-1 levels associated with poor functional outcome in patients with aneurysmal subarachnoid hemorrhage?
Population
101 patients with aneurysmal subarachnoid hemorrhage (SAH)
Comparison
Measurement of serum soluble intercellular… vs Control patients without SAH; patients with good…
Design
Cohort
Follow-up
Until discharge
Authors
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Late ICAM-1 elevations may flag higher-risk SAH patients; leaves open whether anti-inflammatory strategies improve outcomes.
Cohort (n=101)
Are elevated serum soluble ICAM-1 levels associated with poor functional outcome in patients with aneurysmal subarachnoid hemorrhage?
p-value: p=<0.01
Elevated late serum soluble ICAM-1 levels are associated with poor functional outcome following aneurysmal subarachnoid hemorrhage, independent of initial hemorrhage severity.
Mack et al. (2002) conducted a cohort in Aneurysmal subarachnoid hemorrhage (n=101). Elevated serum soluble ICAM-1 levels vs. Lower ICAM-1 levels was evaluated on Poor functional outcome (mRS Grades 4-6) (p=<0.01). Elevated serum soluble ICAM-1 levels over the first 2 weeks post-SAH were significantly associated with poor functional outcome (P<0.01).
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