Why the study?
Do factors such as age, renal function, weight, frailty, adherence, and drug interactions influence DOAC concentrations in patients taking direct oral anticoagulants?
Do factors such as age, renal function, weight, frailty, adherence, and drug interactions influence DOAC concentrations in patients taking direct oral anticoagulants?
Therapeutic monitoring of DOAC concentrations in patients with specific risk factors (e.g., advanced age, renal impairment, low weight) could optimize treatment outcomes.
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May warrant DOAC concentration monitoring in frail elderly or renally impaired patients; leaves open obesity effects and needs prospective validation.
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Penka et al. (2023) conducted a review in Patients taking direct oral anticoagulants (DOACs). Clinical factors (advanced age, altered renal function, sarcopenia, obesity, medication adherence, drug interactions) was evaluated on Impact on therapeutic DOAC concentrations.
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