Key result
Higher mean carotid intima-media thickness (fourth vs. first quartile) was associated with an increased risk of sudden cardiac death in the ARIC cohort (HR 1.64; 95% CI 1.15-2.63).
Why the study?
Whether carotid intima-media thickness (C-IMT), a surrogate marker of subclinical atherosclerosis, is associated with SCD risk in a general population remains unknown.
Does higher carotid intima-media thickness increase the risk of sudden cardiac death in a general population?
Population
20 862 participants from the ARIC study (15 307) and CHS (5555)
Comparison
Higher vs lower C-IMT quartiles and presence vs absence of plaque
Design
Two prospective community-based cohort studies
Follow-up
Median 23.5 years in ARIC and 13.1 years in CHS
Authors
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Higher CIMT was associated with SCD risk; leaves open incremental value for risk stratification in primary prevention.
Cohort (n=20,862)
Yes
Does higher carotid intima-media thickness increase the risk of sudden cardiac death in a general population?
Hazard Ratio: 1.64 (95% CI 1.15–2.63)
Carotid intima-media thickness and plaque presence are independent predictors of sudden cardiac death, suggesting their potential utility in early risk stratification.
Suzuki et al. (2020) conducted a cohort in Sudden cardiac death risk (n=20,862). Carotid intima-media thickness (C-IMT) vs. First quartile of C-IMT was evaluated on Sudden cardiac death (HR 1.64, 95% CI 1.15-2.63). Higher mean carotid intima-media thickness (fourth vs. first quartile) was associated with an increased risk of sudden cardiac death in the ARIC cohort (HR 1.64; 95% CI 1.15-2.63).
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