Key result
Severely reduced left ventricular ejection fraction (<30%) in STEMI patients was significantly associated with higher body mass index (31.07 vs 24.98 kg/m2), fasting blood sugar, and leukocyte count.
Why the study?
Reduced LVEF notably worsens prognosis in STEMI, but the link between cardiometabolic risk markers and left ventricular systolic dysfunction remains unclear.
Cross-Sectional (n=200)
No
In patients with STEMI, severely reduced LVEF is associated with higher BMI, elevated fasting blood sugar, and increased leukocyte counts, suggesting a link between cardiometabolic risk markers, inflammation, and left ventricular systolic dysfunction.
Answers are grounded in this paper and cite their sources.
May aid risk stratification in STEMI; hypothesis-generating for cardiometabolic and inflammatory links to severe LV dysfunction and needs prospective validation.
Background It is well established that left ventricular systolic dysfunction (LVSD), as marked by reduced left ventricular ejection fraction (LVEF), notably worsens the prognosis of ST-elevation myocardial infarction (STEMI). However, the link between cardiometabolic risk markers and LVSD seems unclear. This study aimed to investigate the differences in variables affecting reduced LVEF in STEMI patients. Methods In the current retrospective study, 200 consecutive STEMI patients were enrolled between April 2016 to January 2017. Analysis of serum parameters, anthropometric evaluation, and echocardiography was performed after admission. The participants were categorized according to LVEF levels as follows: group1 (normal: 50–70%, n = 35), group2 (mildly reduced: 40–49%, n = 48); group3 (moderately reduced: 30–39%, n = 94) and group4 (severely reduced: < 30%, n = 23). Between-group comparisons were made using the Kruskal–Wallis test. Results Overall, of 200 STEMI patients with a mean age of 62 years, 27%(n = 54) were females. The median of BMI of patients in group4 (31.07 kg/m 2 ) was significantly higher than group3 (26.35 kg/m 2 ), group2 (25.91 kg/m 2 ), and group1 (24.98 kg/m 2 ; P value < 0.0001). Group4 patients showed significantly increased fasting blood sugar (FBS) than groups 1 (212.00, vs. 139.00 mg/dl; P value = 0.040). Patients in groups 1 and 2 exerted significantly elevated triglyceride levels than those in group4 (142.00, 142.50, and 95.00 mg/dl; P value = 0.001). WBC count, neutrophil%, and neutrophil to lymphocyte ratio among those in group1 (10,200/m 3 , 70.00%, and 2.92, respectively) were significantly lower than group4 (12,900/m 3 , 83.00%, and 5.47, respectively; P value < 0.05). Conclusion These findings highlight higher BMI, FBS, and leucocyte count linked to LVSD, probably through increasing the inflammation and reducing LVEF levels. More extensive studies are needed to clarify the clinical relevance of these results.
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Mahdavi‐Roshan et al. (2022) conducted a cross-sectional in ST-elevation myocardial infarction (STEMI) (n=200). Severely reduced LVEF (<30%) vs. Normal LVEF (50-70%) was evaluated on Body mass index (BMI) (p=<0.0001). Severely reduced left ventricular ejection fraction (<30%) in STEMI patients was significantly associated with higher body mass index (31.07 vs 24.98 kg/m2), fasting blood sugar, and leukocyte count.
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