Prevalence and Prognostic Implications of Reduced Left Ventricular Ejection Fraction Among Patients with STEMI in India
Key result
LVEF <30% linked to ~3.6-fold higher mortality vs preserved LVEF in STEMI.
- HR 3.63
- 95% CI 2.41-5.48
- n=3,597
Why the study?
Clinical characteristics and outcomes for patients with STEMI and reduced LVEF in low-income and middle-income countries were not well described.
Population
3597 adults presenting with STEMI in two government-owned tertiary care centres in Delhi, India
Comparison
LVEF categories: >50%, 40-49%, 30-39%, <30%
Design
Prospective registry-based cohort study
Follow-up
1 year
Authors
Discussion
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Implication
Reduced LVEF stratifies 1-year mortality risk after STEMI; extends observational data but leaves open effects of GDMT adherence interventions.
Study Design
Type
Cohort (n=3,597)
Multicenter
Yes
Structured PICO
P
Population
3,597 adults presenting with STEMI to two tertiary care centers in Delhi, India, evaluated for LVEF and followed for 1 year.
O
Outcome
All-cause mortality at 1 yearhard clinical
Main Result
Hazard Ratio: 3.63 (95% CI 2.41–5.48)
Among STEMI patients in India, reduced LVEF is highly prevalent and strongly associated with 1-year mortality, compounded by poor long-term adherence to guideline-directed medical therapy.
Cite This Study
Hendrickson et al. (2022) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=3,597). Severely reduced LVEF (<30%) vs. LVEF ≥50% was evaluated on all-cause mortality (HR 3.63, 95% CI 2.41-5.48). Severely reduced LVEF (<30%) was associated with an increased risk of all-cause mortality compared with LVEF ≥50% among patients with STEMI (HR 3.63; 95% CI 2.41-5.48).