Key result
The neutrophil-to-lymphocyte ratio independently predicted postoperative mortality (OR 1.159; 95% CI 1.022-1.314; p=0.021) and right ventricular failure in patients receiving LVADs.
Why the study?
Does a higher neutrophil-to-lymphocyte ratio predict postoperative mortality and right ventricular failure in patients with advanced heart failure receiving LVADs?
Cohort (n=273)
No
Does a higher neutrophil-to-lymphocyte ratio predict postoperative mortality and right ventricular failure in patients with advanced heart failure receiving LVADs?
Answers are grounded in this paper and cite their sources.
The neutrophil-to-lymphocyte ratio is a simple, practical biomarker that independently predicts postoperative mortality, right ventricular failure, and length of stay in patients receiving LVADs.
The neutrophil-to-lymphocyte ratio (NLR) has been used to predict mortality in a wide range of cardiovascular diseases including acute decompensated heart failure and non-ST-elevation myocardial infarction. We investigated the prognostic utility of the NLR in patients with advanced heart failure who received left ventricular assist devices (LVADs). Two hundred seventy-three patients implanted with LVADs at our institution were divided into tertiles based on their NLR and were retrospectively analyzed. Outcomes, including survival and right ventricular (RV) failure, were compared between tertiles. The NLR was found to be an independent predictor of postoperative mortality (odds ratio [OR] = 1.159, confidence interval [CI] = 1.022-1.314, p = 0.021) and of postoperative RV failure (OR = 1.117, CI = 1.039-1.201, p = 0.003). In addition, patients in the highest NLR tertile were found to have significantly increased postoperative length of stay (tertile 1 = 20.6 ± 10.7 days, tertile 2 = 24.2 ± 20.7 days, and tertile 3 = 28.8 ± 18.6 days, p = 0.001). In conclusion, the NLR is a simple and practical method for predicting adverse outcomes including all-cause mortality and RV failure after LVAD implantation.
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Yost et al. (2015) conducted a cohort in Advanced heart failure requiring left ventricular assist device (LVAD) (n=273). Neutrophil-to-lymphocyte ratio (NLR) vs. Lower NLR tertiles was evaluated on Postoperative mortality (OR 1.159, 95% CI 1.022-1.314, p=0.021). The neutrophil-to-lymphocyte ratio independently predicted postoperative mortality (OR 1.159; 95% CI 1.022-1.314; p=0.021) and right ventricular failure in patients receiving LVADs.
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