Key result
Patients with a peak oxygen uptake <10 mL·kg⁻¹·min⁻¹ had a four-fold higher incidence of post-operative cardiac and pulmonary morbidity compared to those with >17 mL·kg⁻¹·min⁻¹.
Why the study?
What are the predictors of post-operative cardiopulmonary morbidity in lung cancer patients with reduced lung function undergoing surgery?
Population
210 consecutive patients with lung cancer and forced expiratory volume in 1 s <80% predicted, who underwent…
Design
Cohort
Follow-up
post-operative
Authors
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Low peak VO2 identifies high-risk lung cancer surgery patients; hypothesis-generating for CPET-guided stratification pending prospective trials.
Observational (n=210)
What are the predictors of post-operative cardiopulmonary morbidity in lung cancer patients with reduced lung function undergoing surgery?
Effect estimate: 4-fold higher incidence
Pre-operative peak oxygen uptake and intra-operative factors like anaesthesia duration and tidal volume are independent predictors of post-operative cardiopulmonary complications in lung cancer surgery patients with reduced lung function.
Licker et al. (2010) conducted an observational in Lung cancer (n=210). Peak oxygen uptake <10 mL·kg⁻¹·min⁻¹ vs. Peak oxygen uptake >17 mL·kg⁻¹·min⁻¹ was evaluated on Post-operative cardiopulmonary morbidity (4-fold higher incidence). Patients with a peak oxygen uptake <10 mL·kg⁻¹·min⁻¹ had a four-fold higher incidence of post-operative cardiac and pulmonary morbidity compared to those with >17 mL·kg⁻¹·min⁻¹.
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