June 1, 1988Circulation ResearchOpen Access

Potassium-induced release of endothelium-derived relaxing factor from canine femoral arteries.

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Population

Canine femoral artery segments with endothelium and canine coronary artery rings without endothelium

Comparison

Elevated extracellular K+ concentration via… vs Baseline K+ concentration, endothelium removal…

Design

Preclinical

Authors

Discussion

Hypothesis-generating for potassium-mediated endothelial relaxation in animals; leaves open relevance to human vasoregulation.

Population

Canine femoral artery segments with endothelium (donor segment) and canine coronary artery rings without endothelium (bioassay tissue)

Intervention

Elevated extracellular K+ concentration (from 5.9 mM to 7.5-45.9 mM) via potassium chloride

Comparator

Baseline K+ concentration, endothelium removal, or Ca2+-deficient solution

Outcome

Release of endothelium-derived relaxing factor (measured by relaxation of bioassay rings contracted with prostaglandin F2 alpha)surrogate

Elevated extracellular potassium induces the calcium-dependent release of endothelium-derived relaxing factor from canine femoral arteries.

Rubanyi et al. (1988) studied this question.

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