Population
Canine coronary artery rings
Comparison
Incubation of the bioassay ring with ouabain vs Response without ouabain / differential response…
Design
Preclinical
Authors
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Supports distinct EDRFs in coronary endothelium; leaves open translation to human vessels and clinical relevance.
This preclinical study demonstrates the existence of at least two distinct endothelium-derived relaxing factors in canine coronary arteries that can be differentiated by their sensitivity to ouabain.
Hoeffner et al. (1989) studied this question.
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