What question did this study set out to answer?

To determine whether serum cardiac troponin I concentrations differ between healthy cats and cats diagnosed with hypertrophic cardiomyopathy.

June 30, 2003Journal of Feline Medicine and SurgeryOpen Access

Cardiac troponin I in cats with hypertrophic cardiomyopathy

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Why the study?

Does serum cTnI concentration differ between cats with hypertrophic cardiomyopathy and normal cats?

Population

34 cats (16 diagnosed with hypertrophic cardiomyopathy using echocardiography, 18 control cats)

Comparison

Measurement of serum cardiac troponin I (cTnI) vs Control cats

Design

Preclinical

Authors

DCDJ ConnollyUniversity of London ABAdrian BoswoodUniversity of London JAJoy ArcherUniversity of Cambridge

Discussion

Member takes

Implication

May support cTnI as a feline HCM biomarker; hypothesis-generating and leaves open prospective validation before clinical use.

Key Points

To determine whether serum cardiac troponin I concentrations differ between healthy cats and cats diagnosed with hypertrophic cardiomyopathy.
Assessed serum cardiac troponin I (cTnI) concentrations in 16 cats with hypertrophic cardiomyopathy confirmed by echocardiography and 18 healthy control cats.
Evaluated the correlation between left ventricular freewall thickness in diastole measured via ultrasound and circulating cTnI levels.
Cats with hypertrophic cardiomyopathy had significantly higher serum cTnI levels (median 0.95 ng/ml, range 0.2–4.1 ng/ml) than control cats (median <0.2 ng/ml, range <0.2–0.25 ng/ml; P < 0.0001).
A weak positive correlation was identified between serum cTnI concentration and left ventricular freewall thickness in diastole in affected cats (r² = 0.28, P = 0.036).

Structured PICO

Does serum cTnI concentration differ between cats with hypertrophic cardiomyopathy and normal cats?

Population

34 cats (16 diagnosed with hypertrophic cardiomyopathy using echocardiography, 18 control cats)

Intervention

Measurement of serum cardiac troponin I (cTnI)

Comparator

Control cats

Outcome

Serum cTnI concentrationssurrogate

Serum cTnI concentration is significantly elevated in cats with hypertrophic cardiomyopathy and correlates weakly with left ventricular freewall thickness, suggesting its potential utility as a diagnostic biomarker in veterinary cardiology.

Cite This Study

Connolly et al. (2003) studied this question.

synapsesocial.com/papers/6a81ad55bcfc941b47bf67ab https://doi.org/10.1016/s1098-612x(03)00007-x

Topics

Echocardiography Hypertrophic cardiomyopathy

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Cardiac troponin I in cats with hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cardiac troponin I in cats with hypertrophic cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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