Key result
Increased interventricular septum thickness strongly correlates with elevated cardiac troponin I in canine HCM.
Why the study?
Hypertrophic cardiomyopathy is considered rare in dogs with a lack of clinical data, prompting investigation into whether cTnI combined with echocardiography can diagnose canine HCM.
Can the presence of cTnI in clinical data be used in conjunction with echocardiography to diagnose canine HCM?
Observational (n=10)
No
Can the presence of cTnI in clinical data be used in conjunction with echocardiography to diagnose canine HCM?
Effect estimate: r = 0.839
p-value: p=0.01
In dogs with concentric hypertrophy, ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of hypertrophic cardiomyopathy.
May support presumptive canine HCM diagnosis with echocardiography; hypothesis-generating and requires prospective validation before routine use.
Background: Hypertrophic cardiomyopathy (HCM) is considered rare in dogs, and there is a lack of clinical data. Cardiac troponin I (cTnI) is a biomarker of cardiomyocyte damage and necrosis and can be used to diagnose cat and human HCM. Aim: We investigated whether the presence of cTnI in clinical data can be used in conjunction with echocardiography to diagnose canine HCM. Methods: This study comprised client-owned dogs with clinical evidence of concentric hypertrophy on echocardiographic images, serum total thyroxine levels of ≤5 µg/dl, systolic blood pressure of ≤180 mmHg, and absence of aortic stenosis. All cases were necropsied. Results: = 0.01). Conclusion: Ventricular wall thickening and high serum cTnI levels can provide a presumptive diagnosis of HCM and prompt the initiation of treatment or additional diagnostic investigations.
No takes yet. Share an insight, caveat, or question.
Ando et al. (2023) conducted an observational in Hypertrophic cardiomyopathy (HCM) (n=10). Elevated serum cardiac troponin I (cTnI) and normalized interventricular septum thickness (IVSDN) vs. Healthy dog reference values was evaluated on Correlation between normalized end-diastolic interventricular septum thickness (IVSDN) and serum cTnI levels (r = 0.839, p=0.01). In dogs with hypertrophic cardiomyopathy, elevated normalized interventricular septum thickness strongly correlated with increased serum cardiac troponin I levels (r = 0.839), providing a utility for presumptive diagnosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: