Why the study?
Does prolonged ventricular repolarization predict cardiovascular morbidity and mortality in patients with resistant hypertension?
Population
538 patients with resistant hypertension
Comparison
Prolonged ventricular repolarization vs Normal ventricular repolarization
Design
Cohort
Follow-up
median 4.8 years
Key result
In patients with resistant hypertension, a 1 SD increment in QTcend-interval was associated with an increased risk of the composite cardiovascular endpoint (HR 1.35; 95% CI 1.11-1.66).
Authors
Loading...
QTcend prolongation may flag higher CV risk in resistant hypertension; leaves open incremental value for risk stratification.
Cohort (n=538)
Does prolonged ventricular repolarization predict cardiovascular morbidity and mortality in patients with resistant hypertension?
Hazard Ratio: 1.35 (95% CI 1.11–1.66)
Prolonged ventricular repolarization, specifically QTcend-interval ≥460 ms, is an independent predictor of cardiovascular morbidity and mortality in patients with resistant hypertension.
Salles et al. (2009) conducted a cohort in resistant hypertension (n=538). 1 SD (35 ms) increment in QTcend-interval was evaluated on composite of fatal and nonfatal cardiovascular events, all-cause and cardiovascular mortalities (HR 1.35, 95% CI 1.11-1.66). In patients with resistant hypertension, a 1 SD increment in QTcend-interval was associated with an increased risk of the composite cardiovascular endpoint (HR 1.35; 95% CI 1.11-1.66).