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January 1, 2009Platelets

The effect of ex vivo anticoagulants on whole blood platelet aggregation

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Why the study?

Does the choice of ex vivo anticoagulant affect whole blood platelet aggregation in healthy volunteers?

Population

11 healthy adult volunteers who had not taken any medication in the previous 14 days

Comparison

Whole blood stored in unfractionated heparin… vs Whole blood stored in trisodium citrate

Design

Preclinical

Follow-up

120 minutes

Authors

MKMadeleine L. KalbMedical University of ViennaLPLukasz PoturaMarymount UniversityGSGisela ScharbertMedical University of Vienna

Discussion

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Implication

Citrate may artifactually impair aggregation readings; leaves open optimal ex vivo anticoagulant for clinical platelet aggregometry.

Structured PICO

Does the choice of ex vivo anticoagulant affect whole blood platelet aggregation in healthy volunteers?

P
Population
11 healthy adult volunteers who had not taken any medication in the previous 14 days
I
Intervention
Whole blood stored in unfractionated heparin, melagatran, lepirudin, and argatroban
C
Comparator
Whole blood stored in trisodium citrate
O
Outcome
Platelet aggregation measured by impedance aggregometry with ADP, TRAP, collagen, arachidonic acid, and ristocetin at baseline, 30, and 120 minutessurrogate

Direct thrombin inhibitors and unfractionated heparin are preferred over citrate as ex vivo anticoagulants for accurate point-of-care whole blood platelet aggregometry.

Cite This Study

Kalb et al. (2009) studied this question.

synapsesocial.com/papers/6a81b489f453150ffdd81fc2https://doi.org/10.1080/09537100802364076

Topics

Anticoagulation in AF
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