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August 4, 2020Journal of Clinical MedicineOpen Access

Effects of Time-Interval since Blood Draw and of Anticoagulation on Platelet Testing (Count, Indices and Impedance Aggregometry): A Systematic Study with Blood from Healthy Volunteers

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Why the study?

Platelet count, indices, and aggregation are widely used to assess primary hemostasis, but the influence of time since blood draw and anticoagulant type requires systematic evaluation.

How do the time-interval since blood draw and the type of anticoagulation affect platelet count, indices, and aggregation in healthy volunteers?

Population

20 healthy individuals

Comparison

Citrate vs K2-EDTA vs hirudin anticoagulation analyzed 5, 30, 60, 120, and 180 min after draw

Follow-up

180 min

Authors

MHMichaël HardySLSarah LessireSKSultan Kasikci

Discussion

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Member takes

Overview

Requires standardized preanalytical conditions for reliable aggregometry; leaves optimal timing and anticoagulant open for validation.

Structured PICO

How do the time-interval since blood draw and the type of anticoagulation affect platelet count, indices, and aggregation in healthy volunteers?

P
Population
20 healthy individuals
I
Intervention
Blood anticoagulated with citrate, EDTA, or hirudin and analyzed at 5, 30, 60, 120, and 180 minutes after blood draw
C
Comparator
Comparisons between different anticoagulants and time intervals
O
Outcome
Platelet count, indices (mean volume, immature platelet fraction), and aggregation (multiple electrode aggregometry)surrogate

Preanalytical variables such as time since blood draw and type of anticoagulant significantly affect platelet testing results, highlighting the need for standardized preanalytical conditions.

Cite This Study

Hardy et al. (2020) studied this question.

synapsesocial.com/papers/6a83faf3a3cef8348e997e6dhttps://doi.org/10.3390/jcm9082515
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Time dependent reduction in platelet aggregation using the multiplate analyser and hirudin blood due to platelet clumping2017 · 17 citations
  2. 2Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: A comparison between citrate and hirudin2012 · 17 citations
  3. 3The effects of time interval after venipuncture and of anticoagulation on platelet adhesion and aggregation1996 · 11 citations
  4. 4Platelet function testing in hirudin and BAPA anticoagulated blood2010 · 19 citations
  5. 5The effect of ex vivo anticoagulants on whole blood platelet aggregation2009 · 87 citations