Why the study?
Does NTG preexposure concentration, duration, and nitrate-free period determine NTG tolerance, and does N-acetylcysteine attenuate it in isolated coronary arteries?
Population
Isolated coronary artery preparation
Comparison
Nitroglycerin preexposure and sulfhydryl… vs Non-tolerant tissues or tissues without…
Design
Preclinical
Authors
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NTG dosing parameters may shape tolerance in isolated arteries; leaves open optimal intervals and NAC utility in patients.
Does NTG preexposure concentration, duration, and nitrate-free period determine NTG tolerance, and does N-acetylcysteine attenuate it in isolated coronary arteries?
In an isolated coronary artery model, nitroglycerin tolerance depends on exposure concentration and duration, as well as the nitrate-free interval, but is not reversed by N-acetylcysteine.
Henry et al. (1989) studied this question.
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