Key result
Citrus hystrix peel ethanolic extract repaired the cardiohistopathology profile of doxorubicin-induced cardiotoxicity in rats, but did not improve hepatohistopathology or reduce ALT and AST.
Why the study?
Does Citrus hystrix peel extract prevent doxorubicin-induced cardiotoxicity and hepatotoxicity in female Sprague Dawley rats?
Population
Female Sprague Dawley rats (n=15)
Comparison
Citrus hystrix peel ethanolic extract 500 mg/kg… vs Doxorubicin 4.67 mg/kg alone and untreated control
Design
Preclinical
Follow-up
11 days
Authors
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May support further rat-model validation of selective cardioprotection; leaves open any clinical translation for doxorubicin toxicity.
Does Citrus hystrix peel extract prevent doxorubicin-induced cardiotoxicity and hepatotoxicity in female Sprague Dawley rats?
Citrus hystrix peel extract shows potential as a cardioprotective agent against doxorubicin-induced cardiotoxicity in a rat model.
Putri et al. (2013) studied Doxorubicin-induced cardiotoxicity and hepatotoxicity. Citrus hystrix peel ethanolic extract (ChEE) vs. Doxorubicin alone, untreated control was evaluated on Blood serum ALT and AST activity and cardio-hepato-histopathology. Citrus hystrix peel ethanolic extract repaired the cardiohistopathology profile of doxorubicin-induced cardiotoxicity in rats, but did not improve hepatohistopathology or reduce ALT and AST.
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