Key result
End-stage renal disease was associated with significantly lower global longitudinal strain and global work efficiency, and higher peak strain dispersion and global wasted work compared to controls (p<0.05).
Why the study?
This study aimed to use noninvasive left ventricular pressure-strain loop technology for the early identification of changes in left ventricular structure and myocardial work in patients with end-stage renal disease.
Does left ventricular pressure-strain loop (LV-PSL) identify early changes in left ventricular structure and myocardial work in patients with end-stage renal disease?
Cross-Sectional (n=102)
Does left ventricular pressure-strain loop (LV-PSL) identify early changes in left ventricular structure and myocardial work in patients with end-stage renal disease?
p-value: p=<0.05
LV-PSL can identify subclinical left ventricular structural and functional abnormalities, such as increased wasted work and decreased efficiency, in patients with ESRD.
LV-PSL may detect subclinical myocardial work abnormalities in ESRD; hypothesis-generating and requires prospective validation before clinical adoption.
INTRODUCTION: A new and noninvasive technology of left ventricular pressure-strain loop (LV-PSL) has recently been used to provide information on myocardial work (MW) and identify subtle modifications in cardiac function. This study aimed to use LV-PSL for early identification of changes in left ventricular (LV) structure and MW in patients with end-stage renal disease (ESRD). METHODS: Seventy-two patients with ESRD were divided into two groups based on undergoing maintenance hemodialysis (MHD), namely, the dialysis group (ESRD-D group) and non-dialysis group (ESRD-ND group). Thirty age- and sex-matched control participants were enrolled in the N group. Traditional echocardiography and LV-PSL measurements were conducted. The values of global longitudinal strain (GLS), peak strain dispersion (PSD), global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE) were assessed. RESULTS: The most prevalent anomaly in ESRD patients was LV hypertrophy. The GLS value was significantly lower, and PSD was higher in patients with ESRD than in controls. Furthermore, patients with ESRD had severely higher GWW values and lower GWE than the N group (p < 0.05). No significant differences were found in GWI and GCW between the three groups (p > 0.05). Correlation analysis showed that GCW, GWI, and GWE were positively correlated with LV ejection fraction (EF) and negatively correlated with GLS. GWW was negatively correlated with LVEF and positively correlated with GLS and PSD. In addition, GWE was negatively correlated with PSD (all p < 0.05). CONCLUSIONS: Patients with ESRD have LV structural and functional abnormalities. LV-PSL measurement can be helpful in identifying these subclinical abnormalities. MHD did not change myocardial workload in patients with ESRD.
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Chen et al. (2025) conducted a cross-sectional in End-stage renal disease (n=102). End-stage renal disease vs. Healthy controls was evaluated on Left ventricular structure and myocardial work parameters (GLS, PSD, GCW, GWW, GWI, GWE) (p=<0.05). End-stage renal disease was associated with significantly lower global longitudinal strain and global work efficiency, and higher peak strain dispersion and global wasted work compared to controls (p<0.05).
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