Key result
Patients with systemic lupus erythematosus had significantly higher global wasted work (109 vs 66 mmHg%; P<0.001) and impaired global work efficiency (95% vs 97%; P<0.001) than normal controls.
Why the study?
Systemic lupus erythematosus is associated with various cardiovascular diseases even in early stages, prompting evaluation of left ventricular systolic function using a novel non-invasive pressure-strain loop technique.
Does the non-invasive pressure-strain loop technique detect impaired left ventricular systolic function in patients with systemic lupus erythematosus compared to normal controls?
Case-Control (n=231)
Does the non-invasive pressure-strain loop technique detect impaired left ventricular systolic function in patients with systemic lupus erythematosus compared to normal controls?
Non-invasive pressure-strain loop echocardiography can detect subclinical left ventricular systolic dysfunction, characterized by increased wasted work and reduced efficiency, in patients with systemic lupus erythematosus.
Pressure-strain loops may detect subclinical LV dysfunction in SLE; hypothesis-generating and requires prospective validation before clinical adoption.
Background: Systemic lupus erythematosus (SLE) is associated with a variety of cardiovascular diseases, even in the early stage of disease development. The purpose of this study was to quantitatively evaluate left ventricular (LV) systolic function in patients with SLE using a novel non-invasive pressure-strain loop (PSL) technique. Methods: This prospective case-control study included 132 patients with SLE and 99 normal controls, all of whom underwent traditional transthoracic echocardiography. The LV myocardial work was evaluated with the PSL technique based on speckle tracking and brachial artery blood pressure. The differences among groups were compared, and the correlations between myocardial work, laboratory data, and disease activity were analyzed in the SLE group. Results: Compared with the normal group, SLE patients had significantly higher global wasted work {GWW; SLE: 109 [82-150] mmHg%; controls: 66 [45-109] mmHg%; P<0.001} and impaired global work efficiency [GWE; SLE: 95% (94-97%); controls: 97% (96-98%); P<0.001]. Global work index (GWI) and global constructive work (GCW) did not show significant differences (P>0.05). Further subdivision analysis found that the increase of GWW and the damage of GWE were more obvious in SLE patients with high disease activity or severe diastolic dysfunction. Multivariate analysis revealed that increased erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-phospholipid antibodies, peak strain dispersion, and SLE Disease Activity Index (SLEDAI) were independently associated with increased GWW (β=0.189, 0.230, 0.444, 0.111, and 0.180, respectively; all P<0.05) and damaged GWE (β=-0.184, -0.130, -0.468, -0.149, and -0.191, respectively; all P<0.05). Conclusions: The non-invasive PSL can quantitatively evaluate the LV systolic function in SLE patients. This technique may provide a new method for monitoring cardiac function in chronic diseases.
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Li et al. (2022) conducted a case-control in Systemic lupus erythematosus (n=231). Systemic lupus erythematosus vs. Normal controls was evaluated on Global wasted work (GWW) (p=<0.001). Patients with systemic lupus erythematosus had significantly higher global wasted work (109 vs 66 mmHg%; P<0.001) and impaired global work efficiency (95% vs 97%; P<0.001) than normal controls.
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