Key result
Renal denervation was not superior to intensified pharmacological treatment with spironolactone for reducing 24-hour systolic blood pressure (decline of 6.4 vs 8.2 mm Hg).
Why the study?
Does renal denervation improve blood pressure reduction compared to spironolactone addition in patients with true resistant hypertension?
RCT (n=106)
randomized
Yes
Does renal denervation improve blood pressure reduction compared to spironolactone addition in patients with true resistant hypertension?
Absolute Event Rate: 6.4% vs 8.2%
In patients with true resistant hypertension, renal denervation is safe but not superior to intensified pharmacological treatment, with spironolactone addition appearing more effective for blood pressure reduction.
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Spironolactone intensification should be prioritized over renal denervation; challenges device superiority in true resistant hypertension.
Rosa et al. (2015) conducted an RCT in true resistant hypertension (n=106). Renal denervation vs. Spironolactone addition (pharmacotherapy) was evaluated on mean 24-hour systolic blood pressure decline. Renal denervation was not superior to intensified pharmacological treatment with spironolactone for reducing 24-hour systolic blood pressure (decline of 6.4 vs 8.2 mm Hg).
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