Why the study?
The study investigated trans-cerebral internal jugular venous-arterial bicarbonate and carbon dioxide tension exchange during acute respiratory acidosis and exercise-induced metabolic acidosis in humans.
Population
Humans undergoing acute respiratory acidosis (n = 39) or metabolic acidosis (n = 24)
Comparison
Acute respiratory acidosis vs exercise-induced metabolic acidosis
Design
Physiological interventional study
Authors
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Differential bicarbonate handling in respiratory acidosis may affect cerebrovascular tone; leaves open clinical relevance in acidotic states.
Increases and decreases in systemic [HCO3-] during acute respiratory and exercise-induced metabolic acidosis differentially affect cerebrovascular acid-base balance.
Caldwell et al. (2021) studied this question.
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