April 1, 1991Journal of Applied Physiology

Analysis of abnormalities of capillary CO2 exchange in vivo

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Population

Mathematical model of capillary gas exchange in vivo

Comparison

Simulated inhibition of erythrocyte HCO-Cl… vs Simulated intact/normal exchange and CA activity

Design

Preclinical

Authors

ABA. BidaniCross-Cutting Cardiology

Discussion

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Implication

Modeling suggests anion exchange is nonessential for CO2 transfer; leaves open its role in microvascular pH stability and requires human validation.

Structured PICO

Population

Mathematical model of capillary gas exchange in vivo

Intervention

Simulated inhibition of erythrocyte HCO(3-)-Cl- exchange, lung carbonic anhydrase (CA) activity, and erythrocyte CA activity

Comparator

Simulated intact/normal exchange and CA activity

Outcome

Overall pulmonary CO2 excretion (VCO2) and required compensatory alterations in cardiac output or mixed venous blood-to-alveolar PCO2 gradient [(delta PCO2)V-A]surrogate

Mathematical modeling suggests that HCO3-Cl- exchange may not be vital for maintaining CO2 transfer but likely plays a more important role in minimizing plasma pH changes during microvascular gas exchange.

Cite This Study

A. Bidani (1991) studied this question.

synapsesocial.com/papers/6a990318cdb6b1cb7af5a8b0 https://doi.org/10.1152/jappl.1991.70.4.1686

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Implication

Modeling suggests anion exchange is nonessential for CO2 transfer; leaves open its role in microvascular pH stability and requires human validation.

Analysis of abnormalities of capillary CO2 exchange in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Analysis of abnormalities of capillary CO2 exchange in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider