Population
Isolated saline-perfused rat lungs
Design
Preclinical
Authors
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Challenges equilibrium models of capillary CO2 transport; leaves open human validation before clinical consideration.
The study demonstrates that traditional equilibrium models of the CO2-HCO3(-)-H+ system are inadequate for investigating capillary CO2 transport, as nonbicarbonate buffer capacity significantly influences reaction kinetics.
Heming et al. (1992) studied this question.
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