Key result
Hypercapnia in isolated rabbit hearts resulted in a smaller increase in perfusate HCO3- concentration compared to in vitro equilibration (delta HCO-3e = 1.6 mM, P<0.01).
Population
Isolated rabbit hearts perfused with rabbit red cells suspended in Ringer solution
Comparison
Hypercapnia for 10 min vs Normal Pco2 (33.4 +/- 0.9 mmHg) for 10 min
Design
Preclinical
Follow-up
10 min
Authors
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Myocardial CO2 buffering via transmembrane exchange is hypothesis-generating in isolated hearts; leaves open relevance to intact or human myocardium.
Mean Difference: 1.6
p-value: p=<0.01
Transmembrane exchange of H+ or HCO3- serves as a buffer mechanism for CO2 in myocardial cells.
Strome et al. (1976) studied this question. Hypercapnia vs. Normal Pco2 was evaluated on Change in perfusate HCO3- concentration (delta HCO-3e = 1.6 mM, p=<0.01). Hypercapnia in isolated rabbit hearts resulted in a smaller increase in perfusate HCO3- concentration compared to in vitro equilibration (delta HCO-3e = 1.6 mM, P<0.01).
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